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High-calorie meals, overweight/obesity, gastrointestinal postprandial oxidative stress (POS), insulin resistance, hyperglycemia, and pancreatic beta-cell dysfunction are examples of risk factors that can modulate both local and systemic OxS in T2D

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There are other important considerations if rational combination therapy is to be safely undertaken

10.1016/j.jmgm.2022.108225 218 SadybekovA