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This may be related to the immunosuppressive effects of nicotine

A young boy described a yellow pack as fun and declared: It makes you feel almost happy by looking at it. It is hard to see children of a similar age enthusing about the new-look packets drab cartons adorned with gruesome images of people with smoking-related diseases

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After outlier removal, the significance and magnitude of all associations persisted in MR-PRESSO (Table 2)