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[49] In the United Kingdom, guidance from the National Institute for Health and Care Excellence notes that, as of February 2025, no nicotine-containing e-cigarettes were licensed as medicines for smoking cessation by the Medicines and Healthcare products Regulatory Agency, and products not licensed as medicines cannot be marketed by manufacturers for stopping smoking

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The laundry list of WHO's concerns includes the lack of conclusive studies and information about electronic-cigarette contents and their long-term health effects, he said

Manufacturers often use a tremendous variety of additives for a number of purposes, including maintaining blend consistency, improving perceived blend quality, as preservatives and even completely changing the organoleptic qualities of the tobacco smoke