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The combination of these adjuvant agents with standard doses of opioids can be used to reduce the risk of complications (e.g., constipation, dizziness, nausea, vomiting, respiratory depression, tolerance, physical dependence) seen in patients using high-dose opioids to alleviate CIPN symptoms

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Although glycine can be synthesized in our body, much of it is also consumed in follow-up reactions, and many of the reactions described above can be reversed or are part of a cycle that sees glycine levels only transiently increased