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A further strength is the use of established methods that conform to proposals and regulatory stipulations on how AL should be assessed ( Synthesis of evidence for abuse liability determination for Velo ONPs Study 1 This study evaluated elements of AL for Velo Pouch products across three nicotine levels (4 mg, 8 mg, and 12 mg nicotine) in comparison to UB cigarette (a high-AL comparator) and NRT gum (a low-AL comparator) in current smokers and smokers who also use STPs

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In both models, nicotine treatment reduced macrophage density in the sensory ganglia and peripheral nerve

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