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By MR, this IV for SmkInit was negatively associated with quantitative measures of hemoglobin (HGB: Effect = -0.07 standard deviation units [95% CI: -0.03 to -0.10 SD units], P = 1x10 -4 ), hematocrit (HCT: Effect = -0.06 [-0.03 - -0.09] SD units, P = 4x10 -4 ), and red blood cell count (RBC: Effect = -0.05 [-0.02 - -0.09] SD units, P = 5x10 -3 ) by the inverse variance weighted (IVW) method ( Fig 1A )

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