glutathione synthesis in liver Frontiers The use of antioxidants in

However, other studies have reported inhibitory effects on neurogenesis in mice [183, 186]

Glutathione is an antioxidant naturally occurring in the body and protects cells from damage caused by free radicals and toxins

050 M), zVAD-fmk (Sigma-Aldrich, 627610

V., Smith, E

In contrast, -LA improved hyperinsulinemia and the higher levels of free fatty acids of the T2DM rats [129], increases antioxidant defense through Nrf2, and reduces inflammation in T2DM (decreases TNF- and Inhibit the expression of NLRP3 and downstream inflammatory factors IL-18 and IL-1) to prevent liver steatosis and relieve HFD-induced liver lipid accumulation in T2DM rats (Table 7)