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High glucose induces human endothelial cell apoptosis through a phosphoinositide 3-kinase-regulated cyclooxygenase-2 pathway

By comparison, the addition of digitonin, a detergent used as a positive control, resulted in a large increase in the cytotoxic signal

It may inhibit the enzyme directly by blocking the enzyme's active sites so it may not perform its function, or it may do this indirectly by acting as a potent antioxidant and cause the elimination of harmful radicals

Accumulation of ROS led to the oxidative stress mediating pathology which was associated with the carcinogenesis (27)

These conditions enable tumor cells to evade immune surveillance