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For a deeper clean, apply a small amount of mild pH-neutral dish soap to a damp cloth, wipe the full interior and exterior surface including the cigar notches, rinse with a clean damp cloth, and dry immediately with a soft towel

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MR-Egger-SIMEX can provide estimation with adjustment for dilution of the MR-Egger estimate using the simulation extrapolation (SIMEX) method, as a supplementary tool for MR-Egger when I 2 GX 0.05)

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