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This is an interesting proposition since a previous study demonstrated that skin ER abundance is not altered by menopause, while dermal ER expression declined by 15% after menopause, 110 suggesting a decline in estrogen hormone action

Reproductive urologists should be included in the comprehensive care of patients with red blood cell disorders, especially when gonadotoxic treatments are being considered, to ensure fertility concerns are appropriately evaluated and managed

Nat Rev Immunol 7:803815

These isotope tracer studies collectively suggest that IDH1-deletion point towards slower or less efficient TCA cycling (presumably due to the diminished anaplerotic flux of IDH1-derived KG)