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After the NMDAR and TRPM4 form a complex, the neurons are more vulnerable to excitotoxicity

Glucose metabolism via the PPP is essential for the generation of NADPH that is required for reductive biosynthetic reactions such as those of cholesterol biosynthesis, bile acid synthesis, steroid hormone biosynthesis, and fatty acid synthesis

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doi: 10.1385/bter:88:1:25 120 DuntasLHMantzouEKoutrasDA

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