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The finding established that the GSH redox cycle is the primary intracellular antioxidant defence system in endothelial cells against peroxide-mediated oxidative stress, and remains a foundational reference for endothelial oxidative stress research using GSH manipulation

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The study notes that tachyphylaxis leading to TSW was more prominent in atopic dermatitis than in pruritus, despite the fact that they are both managed with steroids