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We reasoned that long-term successful quitters versus continuing smokers would experience less intense withdrawal symptoms such as craving because of their diminished tobacco dependence and/or because they no longer experienced the iterative bouts of craving between cigarettes that often occur during ongoing smoking (14, 15)

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Molecular epidemiology studies, in particular of the TP53 , KRAS and epidermal growth factor receptor ( EGFR ) genes, demonstrate strikingly different mutation patterns and frequencies between lung cancers in never smokers and smokers