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These approaches are fundamentally different from traditional CNS drugs, as they work holistically through the gut-brain axis, potentially influencing multiple pathways (immune, metabolic, neural) simultaneously

Those with sugar imbalances and insulin resistances are particularly vulnerable to a worsening state

10.1042/CS20120661 [DOI] [PubMed] [Google Scholar] 82.Llido JP, Jayanti S, Tiribelli C, Gazzin S

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Insufficient testing No data to show they are safe or effective: Most of these substances are not clinically tested on humans, and none of them have undergone the extensive trials required to gain FDA approval as a medicine