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The attachment coordinates of these ligands may use variously one, two or even all three donor atoms, which would then determine the ligands description as monodentate, bidentate or multidentate

In addition to serine phosphorylation of the insulin receptor, various PKC isoforms have been shown to phosphorylate IRS1 and IRS2 further impairing the ability of these insulin receptor substrates to associate with the insulin receptor and downstream effector proteins such as PI3K

10.1002/app.50729 302 SinghC.MehataA

Reviewer: Chiamaka E