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The mass spectrum in positive ionization mode for complex 2 after 1 min of incubation showed three signals, one at m/z = 613 corresponding to the GSSG and two signals of an iron complex at m/z = 254 and at m/z = 376, corresponding to the [M L] + and [M + Na] + species

Furthermore, the effect of LA (50mg/kg or 100mg/kg) on healthy animals was evaluated in the preliminary experiment, and no changes of renal morphology and function were found in the healthy mice after oral medications of LA (shown in Supplementary Figure 1)

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