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Factors that determine the absorption response in terms of hardware are roughly determined by the high heating temperature and whether or not the tobacco leaves can be heated directly from the inside with a blade or heating core

Aging can also impact the overall function of the respiratory system, including the lungs, airways, muscles, and tissues involved in breathing

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Additional biomarkers of biologically effective dose are (1) protein adducts, in that most carcinogen metabolites that react with DNA also react with proteins, and (2) oxidized damage to DNA bases