Theyre not magic bullets, and they require intelligent implementation, medical oversight, and integration into a comprehensive optimization protocol that includes proper training and nutrition
Interventions aimed at blocking collagen and hyaluronan production, such as a neutralizing antibody against TGF- [127], the angiotensin inhibitor losartan [128,129,130,131], or the antifibrotic drugs tranilast and pirfenidone [132,133,134] have shown promising results in alleviating solid stress and increasing breast tumor blood supply and drug delivery
As one pharmaceutical review noted, "the activation of pro-migratory signals and pro-angiogenic factors by BPC-157 is a double-edged sword." No studies have proven that BPC-157 causes cancer, but the biological plausibility of this concern cannot be dismissed
For researchers and clinicians following this issue, this is the central question in the upcoming FDA decision: is dysesthesia frequent and debilitating enough to justify a special mention in the indications, or even a 12 mg dose reserved for specific patients
Some researchers extend a phase if they are still experiencing significant side effects at the current dose
