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Smoking can aggravate or initiate: Chilblains Frostbite Primary or secondary vasospastic disease (Raynaud phenomenon) Ulceration, in patients with systemic sclerosis Thromboangiitis obliterans (Buerger disease), in which blood clots occur in small blood vessels Cholesterol emboli associated with atherosclerosis Thrombosis caused by thrombophilia, antiphospholipid syndrome or drugs including oral contraceptives

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However, the pictorial warnings made the harms of smoking ever present and vivid, while the usual text warnings were bland, stale, and easy to ignore, Brewer wrote in email to Reuters Health

August 28, 1909