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22 Building on extensive evidence, particularly the established relationship between cigarette smoking, GPR15 upregulation, and T-cell function and trafficking, we hypothesized that GPR15 + T cells play a pivotal role in mediating the differential impact of cigarette smoke on the pathogenesis of CD and UC

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However, a lawsuit[1] was filed in the Cook County Circuit Court on May 31, 2016 challenging the ordinance because it violated Illinois State law, which states a home rule municipality that has not imposed a tax based on the number of units of cigarettes or tobacco products before July 1, 1993, shall not impose such a tax after that date.[2] While the City of Chicago did impose a tax on cigarettes prior to July 1, 1993, it did not impose a tax on other tobacco products prior to July 1, 1993