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Conversely, high protein levels of IGF1 and its receptors, accompanied by a reduction in AKT/mTOR signaling pathways resulting from resistance exercise training, are associated with increased autophagy activity in aged skeletal muscles ( IGF1 expression is significantly reduced in ATG7 knockout mice, indicating that IGF1 plays a beneficial role in regulating autophagy (Zecchini et al., 2019)

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A large preclinical toxicity program run across mice, rats, rabbits, and dogs found BPC-157 well tolerated with no serious treatment-related toxicity, no identifiable lethal dose, and no genotoxic or teratogenic signal, which is the strongest safety data point available by Xu 2020

Cell 185 , 33563374.e22 (2022)

For elbow pain, tendon repair, and joint recovery, the strongest outcomes are reported when peptides are combined with structured physical therapy, nutrition, and sleep not used as standalone interventions