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In conclusion , looking at all this data, cigarette smokers face disease risks that are on average 2 to 5 times higher than those of pipe smokers

6 Hematopoietic System Chronic tissue hypoxia leads to a compensatory increase in red blood cell production and nonspecific myeloproliferation (white blood cells, platelets, and clotting factors), increasing plasma viscosity and a prothrombotic state

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