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In animal models, CS directly affects the ET and ME mucosa during both short-term (18 weeks) and long-term (46 months) exposures by causing histologic changes involving goblet cell proliferation and excessive mucus secretion 17,18

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Ongoing marketing and distribution capex are needed to sustain growth, but high gross margins (oral products often 50%+ industry gross margin) mean Velo could become a cash cow as market growth normalizes and fixed infrastructure costs decline