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Participants will be classified as abstinent if they respond no to both of the following questions: (i) have you smoked any cigarettes (even a puff) in the last 7 days? and (ii) Have you used any tobacco product (i.e., chew, snuff, pipe, cigar, etc.) in the last 7 days? Self-report will be biochemically confirmed with expired CO at each in-person visit and urinary anabasine at week 13

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The end of OSH comes alongside dramatic changes at the Center for Tobacco Products at the Food and Drug Administration, including the elimination of the centers management and regulation divisions and the ouster of top tobacco regulator Brian King and head scientist Matthew Farrelly