There is a theoretical case for using both in certain patients, targeting different physiological mechanisms simultaneously, though this approach is under evaluation and not yet standard of care
For most people with a vitamin B12 deficiency, oral supplements are an effective way to bring your levels up to normal, says Foxx, and research backs this up (2)
Everyones goals, body, and treatment schedules are different
Phase Elevated Time Week 9+ Dose nightly 400-500 mcg Notes Higher end if response at 300 mcg is not enough
Patients on this protocol who also use metabolic support agents like Metformin should note that both agents activate AMPK, and physician oversight is warranted to avoid compounding effects on blood glucose that could theoretically cause hypoglycemia in susceptible individuals, though this has not been reported clinically with MOTS-c at standard doses