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The 1858 C/T SNP of the PTPN22 gene is a risk factor for HT because it causes an arginine-tryptophan substitution at codon 620 (R620W), because decreased T cell signaling may results in poorer thymic elimination of autoreactive T cells, or an increased function of PTPN22 may lead to a decrease in regulatory T cells (Tregs) responsible for preventing autoimmunity

The researchers isolate fluconazole-resistant Candida albicans strains from HIV-infected people

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Negrao MV, Skoulidis F, Montesion M, Schulze K, Bara I, Shen V, Xu H, Hu S, Sui D, Elamin YY, Le X, Goldberg ME, Murugesan K, Wu CJ, Zhang J, Barreto DS, Robichaux JP, Reuben A, Cascone T, Gay CM, Mitchell KG, Hong L, Rinsurongkawong W, Roth JA, Swisher SG , Lee J, Tsao A, Papadimitrakopoulou V, Gibbons DL, Glisson BS, Singal G, Miller VA, Alexander B, Frampton G, Albacker LA, Shames D, Zhang J, Heymach JV