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The absence of this protective layer of glycosaminoglycans in patients with interstitial cystitis increases inflammation, which leads to cyst formation and swelling with subsequent pain and irritation.7 In one study, approximately half of the women diagnosed with interstitial cystitis reported symptoms of dysuria.8 Other causative factors of interstitial cystitis have been suggested, including chronic or subclinical infection, autoimmunity, and genetic susceptibility, any of which could be responsible for initiating the inflammatory response

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31 Ejaculatory problems, such as retrograde ejaculation, premature ejaculation, delayed ejaculation (difficulty or inability to achieve ejaculation), and anejaculation (absence of ejaculation), can be underlying factors in male infertility

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The evidence isn't yet at the level of a treatment guideline