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Overall, the impact on the transcriptome of ECA (particularly with ECA 18 W) revealed some alteration in the expression of genes involved in inflammation, oxidative stress, and metabolism of lipids and xenobiotics associated with airway constriction

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Classification Challenges European regulators struggle with how to classify nicotine pouches

For combined cigarette users, the FTND scores were used with an adaptation of the questions, for example, question (4), How many times a day do you use an e-cigarette and how many conventional cigarettes per day do you use? Confounders Our analysis considered two types of confounders: time-independent and time-dependent