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Specifically, demethylation of the NRF2 gene promoter region can activate NRF2 expression, enhancing the binding of transcription factors and regulatory proteins to the promoter, thereby increasing the transcription and protein expression of NRF2

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Although TPL exhibits significant antitumor and anti-inflammatory activities, its clinical application is limited by multi-organ toxicitymainly hepatotoxicity and nephrotoxicitya narrow therapeutic window, and poor physicochemical properties such as low water solubility and a short half-life

Gently rotate without shaking until completely dissolved