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This is backed by a summary of six randomized controlled trials done in humans: AOD9604 had no effect on serum IGF-1 levels, which confirms the hypothesis that AOD9604 does not act via IGF-1

The injectable drug was approved in 2003 under the name Xolair for allergic asthma and later expanded to include chronic hives, but now there was evidence it could also protect against severe allergic reactions to food

(PubMed) Hendler S, Rorvik D, eds

Some patients notice improved energy or mental clarity within 2448 hours, whilst others experience no immediate change, particularly if deficiency is severe

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