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But to make sure our model has not assumed too much about people's response to tax differentials, we acquired a large Midwest cigarette distributor's monthly cigarette sales from January 2006 through September 2008

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But nicotine proved to have a neurologic effect to calm down anger etc, demonstrated in experiments for non-smokers

It also is a cause of coronary hear disease, stroke and a host of other cancers and diseases

PMID 25353061