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Large rCBF reductions were also seen in the striatum, ventromedial PFC, and amygdala, which together with the hippocampus compose a cortico-limbic-striatal circuit proposed to be central to the pathophysiology of psychosis [22]

Dont drink at all if you are under age 21, pregnant or may be pregnant, have health problems that could be made worse by drinking, or are engaging in activities for which alcohol is dangerous (e.g., driving)

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Thus, it is important to understand subgroups of dual users smoking and e-cigarette use behaviors rather than considering all dual users as a homogenous group