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no (coded 0) or yes (coded 1) Indicator variables 3, 4, 5 and 6 provided estimates of the four RRRs for light, medium, heavy and former smoking and comprise the four degrees of freedom of the gender smoking grade interaction

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Data sources This study is based on large-scale Genome-Wide Association Study (GWAS) data, selecting SNPs significantly associated with smoking behavior as instrumental variables

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