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It can lead to the activation of metalloproteinase which can cause degradation of collagen, elastic fibres and proteoglycans

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INTRODUCTION Hyperuricemia (HUA) is a metabolic disease caused by abnormal purine metabolism resulting in abnormally high blood uric acid levels, and several studies have confirmed that baseline uric acid levels are a major predictor of gout attacks 1

Following a fairytale theme, it looked and often felt Tim Burton-esque (think nightmare before Christmas)

[4] The Greek historian Herodotos wrote that the Scythians vaporized cannabis seeds as part of their cultural rituals