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Its job is fundamentally metabolic and hormonal

Mol Pharmacol 93:601611

NRF2 and the hallmarks of cancer

164 Some studies have proposed that a fraction of the AAT protein is S-nitrosylated under physiological conditions, and that AAT nitrosylation is more efficient than the nitrosylation of bovine serum albumin or glutathione

Although superoxide anion and hydrogen peroxide are not particularly reactive they may synergize with specific factors, eg iron, generating potent free radicals such as hydroxyl radical, which may cause direct injury through alteration of vital cellular macromolecules (DNA, protein or lipids)