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doi: 10.1016/j.mam.2008.08.004

It uses very tiny needles to gently puncture the upper layer of skin and create microscopic channels within the dermal and epidermal layers of skin

Fajar JK, Ilmawan M, Mamada SS, et al

It can express transcription factors Mac1 and Ctr1, which promote copper absorption, and can also avoid toxic effects caused by excessive copper accumulation through its unique plasma membrane structure and the activation of the copper resistance assay gene CRD1 [41,42,43,44,45]