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In smokers, a single dose of the xanthine oxidase inhibitor allopurinol restores the acetylcholine-induced endothelium-dependent relaxation response in forearm arteries to nonsmoker levels but does not affect the endothelium-dependent relaxation response in nonsmokers [73]
Examples of nicotine replacement therapy include: Chewing gum Lozenges Nasal sprays Inhalers Patches Medication The FDA has approved 5 different NRTs for quitting nicotine
Figure 2 shows changes in urges to smoke over time after using Juul US and Juul EU
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