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Hence, mitochondrial ALDH2, is a critical enzyme not only for oxidation of acetaldehyde to acetic acid in alcohol metabolism, but also for 4-Hydroxynonenal (4-HNE) metabolism 109,110

[15] The court characterized the Guidance as giving manufacturers a holiday from meeting the obligations of the law, [16] noting that manufacturers can continue to advertise and sell products that are addictive and that target a youth market

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