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Loren Pickart, who isolated and characterized GHK, in the following decades conducted transcriptomic studies showing that GHK-Cu affects the expression of hundreds of genes related to tissue repair, antioxidant, anti-inflammatory and matrix remodeling (Pickart & Margolina 2018

10.1172/JCI58662 41 NishiY.SatohM.NagasuH.KadoyaH.IhoriyaC.KidokoroK.et al (2013)

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Some approaches that reduce obesity or extend lifespan in laboratory models can also negatively affect other tissues, including bone