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Data Availability: All relevant data are within the manuscript and its S1 Data, S1 and S2 Figs, S1S6 Tables files

Despite the risks, methadone may be a more effective treatment option for patients with high levels of physical dependence on opioids

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Un changement dans les tendances de consommation : Avec lvolution des gots et des proccupations des consommateurs, les cigarettes en chocolat ont progressivement t remplaces par dautres confiseries plus modernes