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Before participation, all participants provided written informed consent (or, if under 18 years of age, informed assent with parental consent) in accordance with the institutional review boards of Beth Israel Deaconess Medical Center (Boston, Massachusetts), Emory University (Atlanta, Georgia), the University of Calgary (Alberta, Canada), University of California Los Angeles, University of California San Diego, The University of North Carolina at Chapel Hill, Yale University (New Haven, Connecticut) and Zucker Hillside Hospital (New York) (see Supplementary Information for details)

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