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Following the death of his son Conor in 1991, Clapton's grief was expressed in the song "Tears in Heaven", which peaked at number two on the Billboard Hot 100 and appeared on his Unplugged album

These days, Worthen buys exotic snuffs from around the globe over the internet and mixes up his own blends for himself and friends

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Funding and disclosures: The research is supported by the California Tobacco-Related Disease Research Program (grants T31FT1564 and T32KT5071) and the National Center for Advancing Translational Sciences, National Institutes of Health, through UCSF Clinical and Translational Science Institute (grant UL1 TR001872-06)