Gentiopicrin exerts anti-rheumatic effect in human fibroblast-like synoviocytes via inhibition of p38MAPK/NF-B pathway
The relationship between innate and adaptive immunity underscores their value: innate triggers, such as DAMPs from stressed melanocytes, may initiate adaptive responses via antigen presentation, creating a self-amplifying loop
By integrating transcriptomic and untargeted metabolomic analyses of BM neutrophils, we revealed a pivotal role for Chac2-driven GSH metabolic reprogramming in skewing neutrophils toward the N1 phenotype, which is orchestrated by upstream IFN-I signaling
Their commitment is primarily governed by the mutually inhibitory master regulators retinoic acid-related orphan receptor gamma-t (RORt) (driving the Th17 lineage) and forkhead box P3 (Foxp3) (orchestrating the Treg program), within cytokine milieus that favor either pro-inflammatory (e.g., IL-6, IL-23) or anti-inflammatory (e.g., TGF-, IL-2) outcomes ( Figure 1 )
curcumin, which helps maintain genomic stability and modulates telomere-associated proteins
