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Melatonin supplements and CYP1A2: The CYP1A2 enzyme is one of the enzymes that metabolizes melatonin both the melatonin you naturally produce at night, as well as supplemental melatonin.[ref] If you are a slow CYP1A2 metabolizer, you may not clear out supplemental melatonin as quickly and are likely to have higher serum concentrations

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