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In smokers, the imbalance of OPG/RANK/RANKL signaling pathways was described associated with decreased bone mineral density (BMD) and higher susceptibility to bone fractures 65 , 66 and some studies have attributed these effects to an increase in reactive oxygen species

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Most healthy people are not cognizant of their organslike lungson a daily basis, because they are able to breathe without difficulty and perform their daily tasks without major effort