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[DOI] [PubMed] [Google Scholar] Beck GR Jr, Zerler B, Moran E

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A synthesis method and technology of semaglutide, applied in the field of polypeptide drug production, can solve the problems of high separation and purification, limited coupling site, purification of polypeptide fragments, etc., and achieve the solution of purification difficulty, alleviation of difficulty and rapid transformation

This substitution occurs in the prodomain, the region responsible for intracellular trafficking and activity-dependent secretion of BDNF

It was also reported that hepatocarcinogenesis was associated with increase of basophilic or amphophilic foci (Goodman et al