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Zhang et al., found that tumor hypoxia enhances metastasis in non-small cell lung cancer (NSCLC) by selectively promoting the polarization of macrophages toward an M2 phenotype

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Its activity is enhanced by glutamine via O-glycosylation, leading to the translocation and transcriptional stimulation of key transcription factors (HSF-1 and Sp1) required for maximal HSP70 induction [113]

Gut dysbiosis can lead to a buildup of ammonia, which has been tied to brain fog, trouble staying asleep, and frequent night wakings