Another arginine-related pathway involves carbamoyl phosphate synthetase 1 (CPS1), a key enzyme in the urea cycle that regenerates arginine through citrulline recycling
Concurrently, ammonium accumulation remodels the tumor microenvironment by skewing immune cell differentiation toward immunosuppressive phenotypes and activating cancer-associated fibroblasts (106, 107)
It also helps the liver to process toxins, helps with DNA and protein synthesis, and regulates both the nitric oxide cycle and the metabolism of iron
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