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The metabolic reprogramming of these different tumor types remains diverse (4, 17), yet current data suggest that CR may act as a surrogate marker for a common metabolic program associated with tumorigenesis and tumor progression

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An advantage of this approach is that the denominator would represent sales that are ultimately dispensed in retail community pharmacy settings and in outpatient settings (whereas, as mentioned previously, unit reporting under the MDRP represents units typically dispensed only in the retail community pharmacy setting)