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Another possible contributor to the observed cigarette smoking-induced epidermal hyperkeratinization is nicotine which has also been shown to increase various differentiation markers including filaggrin, involucrin, TG1 in keratinocytes 19 mediated by the activation of nicotinic acetylcholine receptors abundant in the skin 28

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Quitting smoking and tobacco use is the most effective method, although this may not be feasible for everyone

Raw M, Ayo-Yusuf O, Chaloupka F, Fiore M, Glynn T, Hawari F, Mackay J, McNeill A, Reddy S